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Twice-weekly treatment with 3 mg/kg of the PEGylated exenatide NLY01 for 5 months reduced IL-1α, TNF-α, and C1q secretion by primary mouse microglia exposed to α-synuclein preformed fibrils, thereby limiting astrocyte conversion to the neurotoxic A1 phenotype (46)
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This physiological effect, combined with actions on the central nervous system's area postrema (the brain's vomiting centre), can trigger feelings of queasiness, particularly during the initial weeks of treatment